Peet was cast as a lead in NBC's Bent. "
In 2010's independent comedy-drama film Please Give Peet co-starred with Catherine Keener and Rebecca Hall; Amanda Peet played a self-centered cosmetologist named Mary. Also that year Amanda Peet portrayed a supporting role in the romantic comedy film She's the One opposite Jennifer Aniston and Cameron Diaz.
She has also appeared in the 1999 drama series Jack & Jill and the 2006 drama series Studio 60 on the Sunset Strip. Featured roles in films such as the 2000 comedy film The Whole Nine Yards brought her wider recognition.